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These hybrids exhibited superior neuroprotective effects and lower cytotoxicity compared with curcumin alone, activated ARE, chelated ferrous ions and scavenged ROS, thereby protecting cells from oxidative stress and ferroptosis, ultimately promoting neuronal survival (104,127,128)
PMID: 28644687 Athersuch TJ, Antoine DJ, Boobis AR, et al
3 The role of herbal medicine in combating Alzheimer's disease AD is a complex neurodegenerative disorder with multifactorial pathological mechanisms, including amyloid- (A) aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress, mitochondrial dysfunction, and synaptic loss
